{"id":2995,"date":"2025-06-24T10:46:21","date_gmt":"2025-06-24T08:46:21","guid":{"rendered":"https:\/\/regenlife.com\/?page_id=2995"},"modified":"2026-02-02T19:21:30","modified_gmt":"2026-02-02T18:21:30","slug":"alzheimer-essai-clinique","status":"publish","type":"page","link":"https:\/\/regenlife.com\/fr\/alzheimer-essai-clinique\/","title":{"rendered":"RECHERCHE &#038; D\u00c9VELOPPEMENT"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row equal_height=\u00a0\u00bbyes\u00a0\u00bb content_placement=\u00a0\u00bbtop\u00a0\u00bb custom_css_code=\u00a0\u00bbLmdlbS1pbWFnZS1jZW50ZXJlZC1ib3glMjAlN0IlMEElMjAlMjAlMjAlMjBtYXJnaW4tYm90dG9tJTNBJTIwMCUzQiUwQSU3RCUwQS5pbWctYm9yZGVyLXJhZGl1cyUyMGltZyU3QiUwQSUyMCUyMCUyMCUyMGJvcmRlci1yYWRpdXMlM0ElMjAzM3B4JTNCJTBBJTdEJTBBLmN1c3RvbS1pbmZvdGV4dCUyMCU3QiUwQSUyMCUyMCUyMCUyMHdpZHRoJTNBJTIwMjIwcHglM0IlMEElN0QlMEElNDBtZWRpYSUyOG1heC13aWR0aCUzQSUyMDk5MXB4JTI5JTdCJTBBJTIwJTIwJTIwJTIwLmN1c3RvbS1pbmZvdGV4dCUyMCU3QiUwQSUyMCUyMCUyMCUyMCUyMCUyMCUyMCUyMHdpZHRoJTNBJTIwMjAwcHglM0IlMEElMjAlMjAlMjAlMjAlN0QlMEElN0Q=\u00a0\u00bb thegem_revesrse_columns_mobile=\u00a0\u00bbtrue\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1751012676915{margin-bottom: 0px !important;padding-top: 85px !important;padding-bottom: 85px !important;}\u00a0\u00bb tablet_padding_top=\u00a0\u00bb160&Prime; el_class=\u00a0\u00bbCONTENEDORPIRATA\u00a0\u00bb mobile_padding_top=\u00a0\u00bb45&Prime;][vc_column width=\u00a0\u00bb1\/2&Prime; css=\u00a0\u00bb.vc_custom_1750698481768{padding-top: 0px !important;padding-right: 75px !important;}\u00a0\u00bb tablet_padding_right=\u00a0\u00bb42&Prime; mobile_padding_bottom=\u00a0\u00bb60&Prime; mobile_padding_right=\u00a0\u00bb21&Prime; el_class=\u00a0\u00bbINTROPIRATA\u00a0\u00bb]<div class=\"thegem-te-heading thegem-custom-69f81ce03546e6735\" ><h1 id=\"thegem-heading-69f81ce03543c\" class=\"thegem-heading title-h2 vc_custom_1770055983052\" style=\"text-align: left;\" ><span>D\u00c9VELOPPEMENT TH\u00c9RAPEUTIQUE<\/span><\/h1><style type=\"text\/css\">#thegem-heading-69f81ce03543c {margin: 0;}#thegem-heading-69f81ce03543c a:hover, #thegem-heading-69f81ce03543c a:hover span.colored {color: var(--thegem-to-menu-level1-color-hover, #00BCD4) !important;}<\/style><\/div><style>@media screen and (max-width: 1023px) {.thegem-te-heading.thegem-custom-69f81ce03546e6735{display: block!important;}}@media screen and (max-width: 767px) {.thegem-te-heading.thegem-custom-69f81ce03546e6735{display: block!important;}}@media screen and (max-width: 1023px) {.thegem-te-heading.thegem-custom-69f81ce03546e6735{position: relative !important;}}@media screen and (max-width: 767px) {.thegem-te-heading.thegem-custom-69f81ce03546e6735{position: relative !important;}}<\/style>[vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<h4 style=\"text-align: left;\"><span style=\"color: #69abb4;\"><strong><span style=\"color: #aa689e;\">LA MALADIE D\u2019ALZHEIMER<\/span> <\/strong><\/span><\/h4>\n<p>[\/vc_column_text]<div class=\"thegem-te-heading thegem-custom-69f81ce0355618607\" ><h3 id=\"thegem-heading-69f81ce035536\" class=\"thegem-heading text-body\" style=\"text-align: left;\" ><span>La d\u00e9mence de type Alzheimer et les syndromes apparent\u00e9s repr\u00e9sentent un enjeu de sant\u00e9 publique majeur avec 57 millions de cas dans le monde dont 1,2 million en France. Des chiffres qui devraient tripler d\u2019ici 2050 avec le vieillissement de la population. <br \/>\nPathologie neurod\u00e9g\u00e9n\u00e9rative progressive affectant le cerveau, la maladie d&#039;Alzheimer se manifeste principalement par des troubles de la m\u00e9moire, mais elle impacte aussi le langage, le raisonnement, le comportement et l\u2019autonomie. Source de morbidit\u00e9, d\u2019invalidit\u00e9 et de mortalit\u00e9, elle a de fortes cons\u00e9quences sociales et \u00e9conomiques avec un co\u00fbt mondial annuel estim\u00e9 \u00e0 1 300 milliards de $. <\/span><\/h3><style type=\"text\/css\">#thegem-heading-69f81ce035536 {margin: 0;}#thegem-heading-69f81ce035536 a:hover, #thegem-heading-69f81ce035536 a:hover span.colored {color: var(--thegem-to-menu-level1-color-hover, #00BCD4) !important;}<\/style><\/div><style>@media screen and (max-width: 1023px) {.thegem-te-heading.thegem-custom-69f81ce0355618607{display: block!important;}}@media screen and (max-width: 767px) {.thegem-te-heading.thegem-custom-69f81ce0355618607{display: block!important;}}@media screen and (max-width: 1023px) {.thegem-te-heading.thegem-custom-69f81ce0355618607{position: relative !important;}}@media screen and (max-width: 767px) {.thegem-te-heading.thegem-custom-69f81ce0355618607{position: relative !important;}}<\/style>[\/vc_column][vc_column width=\u00a0\u00bb1\/2&Prime; css=\u00a0\u00bb.vc_custom_1750698153438{padding-top: 90px !important;}\u00a0\u00bb mobile_padding_top=\u00a0\u00bb175&Prime; el_class=\u00a0\u00bbIMAGENPIRATA\u00a0\u00bb]<div class=\"centered-box gem-image-centered-box\" ><div class=\"gem-image gem-wrapbox gem-wrapbox-style-default gem-wrapbox-position-centered img-border-radius thegem-custom-69f81ce0355a63535\"  style=\"\" ><div class=\"gem-wrapbox-inner \" ><img class=\"gem-wrapbox-element img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/11\/Woman-8-buste-et-ventre.jpg\" alt=\"\"\/><\/div><\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=\u00a0\u00bbstretch_row\u00a0\u00bb custom_css_code=\u00a0\u00bbLmN1c3RvbS10aXRsZSUyMGgyJTdCJTBBJTIwJTIwJTIwJTIwbWFyZ2luLXJpZ2h0JTNBJTIwMzBweCUyMWltcG9ydGFudCUzQiUwQSUyMCUyMCUyMCUyMG1hcmdpbi1ib3R0b20lM0ElMjAwJTIxaW1wb3J0YW50JTNCJTBBJTIwJTIwJTIwJTIwbWFyZ2luLXRvcCUzQSUyMDAlMjFpbXBvcnRhbnQlM0IlMEElN0QlMEEuY3VzdG9tLXRpdGxlJTIwLnZjX3NlcF9saW5lJTIwJTdCJTBBJTIwJTIwJTIwJTIwdG9wJTNBJTIwMTJweCUyMWltcG9ydGFudCUzQiUwQSU3RCUwQS5nZW0taW5mb3RleHQlMjAlN0IlMEElMjAlMjAlMjAlMjB3aWR0aCUzQSUyMGF1dG8lMjFpbXBvcnRhbnQlM0IlMEElN0QlMEEuZ2VtLWluZm90ZXh0JTNBaG92ZXIlMjAlN0IlMEElMjAlMjAlMjAlMjBiYWNrZ3JvdW5kLWNvbG9yJTNBJTIwJTIzRjlFQUQ1JTIwJTIxaW1wb3J0YW50JTNCJTBBJTIwJTIwJTIwJTIwdHJhbnNpdGlvbiUzQSUyMGFsbCUyMDAuM3MlM0IlMEElN0QlMEE=\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1750698736234{margin-bottom: 0px !important;padding-top: 85px !important;padding-bottom: 85px !important;background-color: #FFFFFF !important;}\u00a0\u00bb][vc_column css=\u00a0\u00bb.vc_custom_1726578677849{padding-top: 0px !important;}\u00a0\u00bb][vc_row_inner content_placement=\u00a0\u00bbbottom\u00a0\u00bb][vc_column_inner]<style type=\"text\/css\">.thegem-button-69f81ce0359356495 .gem-button svg {fill: #000000;}<\/style><div class=\"gem-button-container gem-button-position-left thegem-button-69f81ce0359356495 QUITARLINK   \"  ><a class=\"gem-button gem-button-size-small gem-button-style-flat gem-button-text-weight-normal\" data-ll-effect=\"drop-right-without-wrap\" style=\"border-radius: 0px;background-color: #DDC3D8;color: #000000;\" onmouseleave=\"this.style.backgroundColor='#DDC3D8';this.style.color='#000000';\" onmouseenter=\"\" href=\"\" target=\"_self\" role=\"button\">Essai clinique<\/a><\/div> [\/vc_column_inner][\/vc_row_inner][vc_row_inner content_placement=\u00a0\u00bbbottom\u00a0\u00bb][vc_column_inner][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<h4 style=\"text-align: left;\"><span style=\"color: #69abb4;\"><span data-keyword=\"\"><strong><span style=\"color: #aa689e;\">Traiter la maladie d\u2019Alzheimer <\/span><\/strong><\/span><\/span><\/h4>\n<p>[\/vc_column_text][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<p align=\"justify\"><strong>Malgr\u00e9 les avanc\u00e9es de la recherche, il n\u2019existe pas de traitement pouvant pr\u00e9venir, gu\u00e9rir ou stopper l\u2019\u00e9volution de la maladie d\u2019Alzheimer. Les avanc\u00e9es r\u00e9centes dans les traitements (pharmacologiques et non pharmacologiques), ciblant la physiopathologie de la maladie repr\u00e9sentent une perspective prometteuse rompant avec l\u2019approche symptomatique classique.<\/strong><\/p>\n<p align=\"justify\">Les premi\u00e8res th\u00e9rapies de prise en charge de la maladie d\u2019Alzheimer mises sur le march\u00e9 n&rsquo;\u00e9taient que symptomatiques. De 2003 \u00e0 2021, en d\u00e9pit de nombreux essais cliniques, aucun nouveau traitement contre la maladie d\u2019Alzheimer n\u2019avait \u00e9t\u00e9 approuv\u00e9.<\/p>\n<p align=\"justify\">L\u2019arriv\u00e9e depuis 2021 de traitements ciblant la physiopathologie de la maladie ont marqu\u00e9 un tournant. En effet, les anticorps monoclonaux anti-amylo\u00efdes r\u00e9cemment approuv\u00e9s, par la FDA (\u00c9tats-Unis) et l\u2019EMA (Europe), donnent un nouvel \u00e9lan \u00e0 l&rsquo;espoir d&rsquo;une th\u00e9rapie att\u00e9nuant le d\u00e9clin cognitif. Ces traitements visent \u00e0 diminuer ou \u00e9liminer du cerveau les d\u00e9p\u00f4ts de prot\u00e9ines \u03b2-amylo\u00efde d\u00e9truisant les neurones. Toutefois, des inqui\u00e9tudes persistent quant \u00e0 leur efficacit\u00e9 et leur innocuit\u00e9 \u00e0 long terme. Par ailleurs, d\u2019autres nouvelles approches pharmacologiques (inhibiteurs de l\u2019agr\u00e9gation de tau, immunoth\u00e9rapies\u2026) sont encore en cours d\u2019\u00e9valuation.<\/p>\n<p align=\"justify\">Compte tenu de la complexit\u00e9 de la maladie d\u2019Alzheimer, la n\u00e9cessit\u00e9 d\u2019int\u00e9grer des strat\u00e9gies th\u00e9rapeutiques combin\u00e9es, m\u00e9dicamenteuses et non m\u00e9dicamenteuses, visant divers processus pathologiques, est de plus en plus reconnue. Dans ce contexte, les interventions non pharmacologiques gagnent en importance en tant qu&rsquo;\u00e9l\u00e9ments cl\u00e9s potentiels d&rsquo;un plan th\u00e9rapeutique combin\u00e9 complet.<\/p>\n<p align=\"justify\">Les <a href=\"https:\/\/regenlife.com\/tech-neurostimulation\/\">neurotechnologies et les nouvelles formes de neurostimulation<\/a> bas\u00e9es sur des applications invasives (implantables) et non-invasives (transcr\u00e2niennes) sont tr\u00e8s prometteuses. Ces nouvelles formes de stimulations peuvent \u00eatre d\u2019origine \u00e9lectriques (tES \u2013 transcranial electric stimulation), ultrasonores, magn\u00e9tiques (TMS \u2013 transcranial magnetic stimulation) et photoniques (photobiomodulation transcr\u00e2nienne).<\/p>\n<p align=\"justify\">S\u2019inscrivant dans le secteur des neurotechnologies et de la photom\u00e9decine, REGEnLIFE d\u00e9veloppe un traitement innovant avec une action \u00e0 la fois pr\u00e9ventive et curative\u202f: la stimulation Tri-Photonique. Il s\u2019agit d\u2019une application non-invasive neuro-intestinale agissant essentiellement sur l\u2019inflammation et bas\u00e9e sur une \u00e9mission photonique associ\u00e9e \u00e0 un champ magn\u00e9tique. Ce positionnement technologique et th\u00e9rapeutique est actuellement sans pr\u00e9c\u00e9dent.<\/p>\n<p align=\"justify\">Le traitement d\u00e9velopp\u00e9 par<strong> REGEnLIFE<\/strong> pourra ainsi r\u00e9pondre aux futurs enjeux des traitements combin\u00e9s de <strong>la maladie d\u2019Alzheimer<\/strong>.<\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=\u00a0\u00bbstretch_row_content\u00a0\u00bb background_position_desktop=\u00a0\u00bbleft top\u00a0\u00bb background_position_tablet=\u00a0\u00bbcenter center\u00a0\u00bb custom_css_code=\u00a0\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\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1751013506423{margin-bottom: 0px !important;padding-right: 190px !important;padding-left: 190px !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}\u00a0\u00bb mobile_padding_left=\u00a0\u00bb10&Prime; mobile_padding_right=\u00a0\u00bb10&Prime;][vc_column css=\u00a0\u00bb.vc_custom_1727871320583{padding-top: 90px !important;padding-bottom: 90px !important;}\u00a0\u00bb tablet_padding_top=\u00a0\u00bb70&Prime; tablet_padding_bottom=\u00a0\u00bb70&Prime;][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<h4 style=\"text-align: left;\"><span style=\"color: #69abb4;\"><strong><span style=\"color: #aa689e;\">Les chiffres cl\u00e9s <\/span><\/strong><\/span><\/h4>\n<p>[\/vc_column_text][vc_row_inner equal_height=\u00a0\u00bbyes\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1752047408633{margin-bottom: 0px !important;padding-right: 6px !important;padding-bottom: 0px !important;padding-left: 6px !important;}\u00a0\u00bb mobile_padding_left=\u00a0\u00bb11&Prime; mobile_padding_right=\u00a0\u00bb11&Prime; el_class=\u00a0\u00bbCONTENEDORCAJA7&Prime;][vc_column_inner el_class=\u00a0\u00bbCUADROMINI\u00a0\u00bb width=\u00a0\u00bb7\/12&Prime; css=\u00a0\u00bb.vc_custom_1750756435120{padding-right: 5px !important;padding-bottom: 40px !important;padding-left: 5px !important;}\u00a0\u00bb mobile_padding_bottom=\u00a0\u00bb20&Prime; mobile_padding_left=\u00a0\u00bb10&Prime; mobile_padding_right=\u00a0\u00bb10&Prime; offset=\u00a0\u00bbvc_col-lg-2 vc_col-md-2 vc_col-xs-6&Prime;]<style>.thegem-custom-69f81ce03599e4398 .gem-icon-half-1 {color: #00635F;}.thegem-custom-69f81ce03599e4398 .gem-icon-half-2 {color: #00635F;}.thegem-custom-69f81ce03599e4398 .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #00635F, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.thegem-custom-69f81ce03599e4398 .gem-icon  {font-size: 77px;}.thegem-custom-69f81ce03599e4398 .gem-icon:not(.gem-simple-icon) .gem-icon-inner {width: 115.5px; height: 115.5px; line-height: 115.5px;}.thegem-custom-69f81ce03599e4398 .gem-icon.gem-simple-icon {width: 77px; height: 77px; line-height: 77px;}.thegem-custom-69f81ce03599e4398 a:hover .gem-infotext-icon .gem-icon-half-1 {color: #000000 !important;}.thegem-custom-69f81ce03599e4398 a:hover .gem-infotext-icon .gem-icon-half-2 {color: #000000 !important;}.thegem-custom-69f81ce03599e4398 a:hover .gem-infotext-icon .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #000000, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.gem-infotext.thegem-custom-69f81ce03599e4398 .gem-infotext-icon {margin-top:-2px !important;}.gem-infotext.thegem-custom-69f81ce03599e4398 .gem-infotext-icon {margin-right:0px !important;}.gem-infotext.thegem-custom-69f81ce03599e4398 .title-customize {color:#FFFFFF !important;}.gem-infotext.thegem-custom-69f81ce03599e4398 a:hover .gem-infotext .title-customize {color:#0D2E37 !important;}.gem-infotext.thegem-custom-69f81ce03599e4398 .title-customize {margin-top:5px !important;}.gem-infotext.thegem-custom-69f81ce03599e4398 .title-customize {margin-bottom:0px !important;}.gem-infotext.thegem-custom-69f81ce03599e4398 .subtitle-customize {color:#000000 !important;}.gem-infotext.thegem-custom-69f81ce03599e4398 .subtitle-customize {margin-top:0px !important;}.gem-infotext.thegem-custom-69f81ce03599e4398 .subtitle-customize {margin-bottom:0px !important;}<\/style><div class=\"gem-infotext CAJADESIETE vc_custom_1753088814900 alignment-center thegem-custom-69f81ce03599e4398\"> <div class=\"gem-infotext-wrap position--top horizonal--center \"> <div class=\"gem-infotext-icon\"> <div class=\"gem-icon gem-simple-icon gem-icon-use-image gem-icon-size-custom\"> <div class=\"gem-icon-inner\"><span class=\"gem-icon-half-1\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_001.png\" alt=\"Icone CAJA\"><\/span><\/span><span class=\"gem-icon-half-2\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_001.png\" alt=\"Icone CAJA\"><\/span><\/span><\/div> <\/div> <\/div> <div class=\"gem-infotext\"> <div class=\"gem-infotext__title\"> <div class=\"title-customize text-body\" style=\"text-align:center;\"> 54 Millions <\/div> <\/div> <div class=\"gem-infotext__subtitle\"> <div class=\"subtitle-customize text-body-tiny\" style=\"text-align:center;\"> Personnes atteintes de d\u00e9mence dans le monde <\/div> <\/div> <\/div> <\/div> <\/div>[\/vc_column_inner][vc_column_inner el_class=\u00a0\u00bbCUADROMINI\u00a0\u00bb width=\u00a0\u00bb7\/12&Prime; css=\u00a0\u00bb.vc_custom_1750756088520{padding-right: 15px !important;padding-bottom: 40px !important;padding-left: 15px !important;}\u00a0\u00bb mobile_padding_left=\u00a0\u00bb10&Prime; mobile_padding_right=\u00a0\u00bb10&Prime; offset=\u00a0\u00bbvc_col-lg-2 vc_col-md-2 vc_col-xs-6&Prime; mobile_padding_bottom=\u00a0\u00bb20&Prime;]<style>.thegem-custom-69f81ce035cb64638 .gem-icon-half-1 {color: #00635F;}.thegem-custom-69f81ce035cb64638 .gem-icon-half-2 {color: #00635F;}.thegem-custom-69f81ce035cb64638 .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #00635F, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.thegem-custom-69f81ce035cb64638 .gem-icon  {font-size: 77px;}.thegem-custom-69f81ce035cb64638 .gem-icon:not(.gem-simple-icon) .gem-icon-inner {width: 115.5px; height: 115.5px; line-height: 115.5px;}.thegem-custom-69f81ce035cb64638 .gem-icon.gem-simple-icon {width: 77px; height: 77px; line-height: 77px;}.thegem-custom-69f81ce035cb64638 a:hover .gem-infotext-icon .gem-icon-half-1 {color: #EEEE22 !important;}.thegem-custom-69f81ce035cb64638 a:hover .gem-infotext-icon .gem-icon-half-2 {color: #EEEE22 !important;}.thegem-custom-69f81ce035cb64638 a:hover .gem-infotext-icon .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #EEEE22, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.gem-infotext.thegem-custom-69f81ce035cb64638 .gem-infotext-icon {margin-top:-2px !important;}.gem-infotext.thegem-custom-69f81ce035cb64638 .gem-infotext-icon {margin-right:0px !important;}.gem-infotext.thegem-custom-69f81ce035cb64638 .title-customize {color:#FFFFFF !important;}.gem-infotext.thegem-custom-69f81ce035cb64638 a:hover .gem-infotext .title-customize {color:#0D2E37 !important;}.gem-infotext.thegem-custom-69f81ce035cb64638 .title-customize {margin-top:5px !important;}.gem-infotext.thegem-custom-69f81ce035cb64638 .title-customize {margin-bottom:0px !important;}.gem-infotext.thegem-custom-69f81ce035cb64638 .subtitle-customize {color:#000000 !important;}.gem-infotext.thegem-custom-69f81ce035cb64638 .subtitle-customize {margin-top:0px !important;}.gem-infotext.thegem-custom-69f81ce035cb64638 .subtitle-customize {margin-bottom:0px !important;}<\/style><div class=\"gem-infotext CAJADESIETE vc_custom_1753088874986 alignment-center thegem-custom-69f81ce035cb64638\"> <div class=\"gem-infotext-wrap position--top horizonal--center \"> <div class=\"gem-infotext-icon\"> <div class=\"gem-icon gem-simple-icon gem-icon-use-image gem-icon-size-custom\"> <div class=\"gem-icon-inner\"><span class=\"gem-icon-half-1\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_002.png\" alt=\"Icone France\"><\/span><\/span><span class=\"gem-icon-half-2\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_002.png\" alt=\"Icone France\"><\/span><\/span><\/div> <\/div> <\/div> <div class=\"gem-infotext\"> <div class=\"gem-infotext__title\"> <div class=\"title-customize text-body\" style=\"text-align:center;\"> 1,2 millon <\/div> <\/div> <div class=\"gem-infotext__subtitle\"> <div class=\"subtitle-customize text-body-tiny\" style=\"text-align:center;\"> Personnes atteintes d\u2019Alzheimer en France. 1 nouveau cas toutes les 3 minutes <\/div> <\/div> <\/div> <\/div> <\/div>[\/vc_column_inner][vc_column_inner el_class=\u00a0\u00bbCUADROMINI\u00a0\u00bb width=\u00a0\u00bb7\/12&Prime; css=\u00a0\u00bb.vc_custom_1750756464268{padding-right: 5px !important;padding-bottom: 40px !important;padding-left: 5px !important;}\u00a0\u00bb offset=\u00a0\u00bbvc_col-lg-2 vc_col-md-2 vc_col-xs-6&Prime; mobile_padding_bottom=\u00a0\u00bb20&Prime; mobile_padding_left=\u00a0\u00bb10&Prime; mobile_padding_right=\u00a0\u00bb10&Prime;]<style>.thegem-custom-69f81ce035f8e4433 .gem-icon-half-1 {color: #00635F;}.thegem-custom-69f81ce035f8e4433 .gem-icon-half-2 {color: #00635F;}.thegem-custom-69f81ce035f8e4433 .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #00635F, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.thegem-custom-69f81ce035f8e4433 .gem-icon  {font-size: 77px;}.thegem-custom-69f81ce035f8e4433 .gem-icon:not(.gem-simple-icon) .gem-icon-inner {width: 115.5px; height: 115.5px; line-height: 115.5px;}.thegem-custom-69f81ce035f8e4433 .gem-icon.gem-simple-icon {width: 77px; height: 77px; line-height: 77px;}.thegem-custom-69f81ce035f8e4433 a:hover .gem-infotext-icon .gem-icon-half-1 {color: #EEEE22 !important;}.thegem-custom-69f81ce035f8e4433 a:hover .gem-infotext-icon .gem-icon-half-2 {color: #EEEE22 !important;}.thegem-custom-69f81ce035f8e4433 a:hover .gem-infotext-icon .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #EEEE22, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.gem-infotext.thegem-custom-69f81ce035f8e4433 .gem-infotext-icon {margin-top:-2px !important;}.gem-infotext.thegem-custom-69f81ce035f8e4433 .gem-infotext-icon {margin-right:0px !important;}.gem-infotext.thegem-custom-69f81ce035f8e4433 .title-customize {color:#FFFFFF !important;}.gem-infotext.thegem-custom-69f81ce035f8e4433 a:hover .gem-infotext .title-customize {color:#0D2E37 !important;}.gem-infotext.thegem-custom-69f81ce035f8e4433 .title-customize {margin-top:5px !important;}.gem-infotext.thegem-custom-69f81ce035f8e4433 .title-customize {margin-bottom:0px !important;}.gem-infotext.thegem-custom-69f81ce035f8e4433 .subtitle-customize {color:#000000 !important;}.gem-infotext.thegem-custom-69f81ce035f8e4433 .subtitle-customize {margin-top:0px !important;}.gem-infotext.thegem-custom-69f81ce035f8e4433 .subtitle-customize {margin-bottom:0px !important;}<\/style><div class=\"gem-infotext CAJADESIETE vc_custom_1753088920813 alignment-center thegem-custom-69f81ce035f8e4433\"> <div class=\"gem-infotext-wrap position--top horizonal--center \"> <div class=\"gem-infotext-icon\"> <div class=\"gem-icon gem-simple-icon gem-icon-use-image gem-icon-size-custom\"> <div class=\"gem-icon-inner\"><span class=\"gem-icon-half-1\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_003.png\" alt=\"Icone C\u00e9phal\u00e9es\"><\/span><\/span><span class=\"gem-icon-half-2\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_003.png\" alt=\"Icone C\u00e9phal\u00e9es\"><\/span><\/span><\/div> <\/div> <\/div> <div class=\"gem-infotext\"> <div class=\"gem-infotext__title\"> <div class=\"title-customize text-body\" style=\"text-align:center;\"> + 10 millions \/ an <\/div> <\/div> <div class=\"gem-infotext__subtitle\"> <div class=\"subtitle-customize text-body-tiny\" style=\"text-align:center;\"> Nouveaux cas de d\u00e9m\u00e9nce chaque ann\u00e9e dans le monde <\/div> <\/div> <\/div> <\/div> <\/div>[\/vc_column_inner][vc_column_inner el_class=\u00a0\u00bbCUADROMINI\u00a0\u00bb width=\u00a0\u00bb7\/12&Prime; css=\u00a0\u00bb.vc_custom_1750756471063{padding-right: 5px !important;padding-bottom: 40px !important;padding-left: 5px !important;}\u00a0\u00bb offset=\u00a0\u00bbvc_col-lg-2 vc_col-md-2 vc_col-xs-6&Prime; mobile_padding_bottom=\u00a0\u00bb20&Prime; mobile_padding_left=\u00a0\u00bb10&Prime; mobile_padding_right=\u00a0\u00bb10&Prime;]<style>.thegem-custom-69f81ce0362714775 .gem-icon-half-1 {color: #00635F;}.thegem-custom-69f81ce0362714775 .gem-icon-half-2 {color: #00635F;}.thegem-custom-69f81ce0362714775 .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #00635F, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.thegem-custom-69f81ce0362714775 .gem-icon  {font-size: 77px;}.thegem-custom-69f81ce0362714775 .gem-icon:not(.gem-simple-icon) .gem-icon-inner {width: 115.5px; height: 115.5px; line-height: 115.5px;}.thegem-custom-69f81ce0362714775 .gem-icon.gem-simple-icon {width: 77px; height: 77px; line-height: 77px;}.thegem-custom-69f81ce0362714775 a:hover .gem-infotext-icon .gem-icon-half-1 {color: #EEEE22 !important;}.thegem-custom-69f81ce0362714775 a:hover .gem-infotext-icon .gem-icon-half-2 {color: #EEEE22 !important;}.thegem-custom-69f81ce0362714775 a:hover .gem-infotext-icon .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #EEEE22, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.gem-infotext.thegem-custom-69f81ce0362714775 .gem-infotext-icon {margin-top:-2px !important;}.gem-infotext.thegem-custom-69f81ce0362714775 .gem-infotext-icon {margin-right:0px !important;}.gem-infotext.thegem-custom-69f81ce0362714775 .title-customize {color:#FFFFFF !important;}.gem-infotext.thegem-custom-69f81ce0362714775 a:hover .gem-infotext .title-customize {color:#0D2E37 !important;}.gem-infotext.thegem-custom-69f81ce0362714775 .title-customize {margin-top:5px !important;}.gem-infotext.thegem-custom-69f81ce0362714775 .title-customize {margin-bottom:0px !important;}.gem-infotext.thegem-custom-69f81ce0362714775 .subtitle-customize {color:#000000 !important;}.gem-infotext.thegem-custom-69f81ce0362714775 .subtitle-customize {margin-top:0px !important;}.gem-infotext.thegem-custom-69f81ce0362714775 .subtitle-customize {margin-bottom:0px !important;}<\/style><div class=\"gem-infotext CAJADESIETE vc_custom_1752492800995 alignment-center thegem-custom-69f81ce0362714775\"> <div class=\"gem-infotext-wrap position--top horizonal--center \"> <div class=\"gem-infotext-icon\"> <div class=\"gem-icon gem-simple-icon gem-icon-use-image gem-icon-size-custom\"> <div class=\"gem-icon-inner\"><span class=\"gem-icon-half-1\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_004.png\" alt=\"Icone Groupe\"><\/span><\/span><span class=\"gem-icon-half-2\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_004.png\" alt=\"Icone Groupe\"><\/span><\/span><\/div> <\/div> <\/div> <div class=\"gem-infotext\"> <div class=\"gem-infotext__title\"> <div class=\"title-customize text-body\" style=\"text-align:center;\"> 152 millions <\/div> <\/div> <div class=\"gem-infotext__subtitle\"> <div class=\"subtitle-customize text-body-tiny\" style=\"text-align:center;\"> Personnes atteintes de d\u00e9mence dans le monde d\u2019ici 2050 <\/div> <\/div> <\/div> <\/div> <\/div>[\/vc_column_inner][vc_column_inner el_class=\u00a0\u00bbCUADROMINI\u00a0\u00bb width=\u00a0\u00bb7\/12&Prime; css=\u00a0\u00bb.vc_custom_1750756477352{padding-right: 5px !important;padding-bottom: 40px !important;padding-left: 5px !important;}\u00a0\u00bb offset=\u00a0\u00bbvc_col-lg-2 vc_col-md-2 vc_col-xs-6&Prime; mobile_padding_bottom=\u00a0\u00bb20&Prime; mobile_padding_left=\u00a0\u00bb10&Prime; mobile_padding_right=\u00a0\u00bb10&Prime;]<style>.thegem-custom-69f81ce036526435 .gem-icon-half-1 {color: #00635F;}.thegem-custom-69f81ce036526435 .gem-icon-half-2 {color: #00635F;}.thegem-custom-69f81ce036526435 .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #00635F, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.thegem-custom-69f81ce036526435 .gem-icon  {font-size: 77px;}.thegem-custom-69f81ce036526435 .gem-icon:not(.gem-simple-icon) .gem-icon-inner {width: 115.5px; height: 115.5px; line-height: 115.5px;}.thegem-custom-69f81ce036526435 .gem-icon.gem-simple-icon {width: 77px; height: 77px; line-height: 77px;}.thegem-custom-69f81ce036526435 a:hover .gem-infotext-icon .gem-icon-half-1 {color: #EEEE22 !important;}.thegem-custom-69f81ce036526435 a:hover .gem-infotext-icon .gem-icon-half-2 {color: #EEEE22 !important;}.thegem-custom-69f81ce036526435 a:hover .gem-infotext-icon .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #EEEE22, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.gem-infotext.thegem-custom-69f81ce036526435 .gem-infotext-icon {margin-top:-2px !important;}.gem-infotext.thegem-custom-69f81ce036526435 .gem-infotext-icon {margin-right:0px !important;}.gem-infotext.thegem-custom-69f81ce036526435 .title-customize {color:#FFFFFF !important;}.gem-infotext.thegem-custom-69f81ce036526435 a:hover .gem-infotext .title-customize {color:#0D2E37 !important;}.gem-infotext.thegem-custom-69f81ce036526435 .title-customize {margin-top:5px !important;}.gem-infotext.thegem-custom-69f81ce036526435 .title-customize {margin-bottom:0px !important;}.gem-infotext.thegem-custom-69f81ce036526435 .subtitle-customize {color:#000000 !important;}.gem-infotext.thegem-custom-69f81ce036526435 .subtitle-customize {margin-top:0px !important;}.gem-infotext.thegem-custom-69f81ce036526435 .subtitle-customize {margin-bottom:0px !important;}<\/style><div class=\"gem-infotext CAJADESIETE vc_custom_1753088977674 alignment-center thegem-custom-69f81ce036526435\"> <div class=\"gem-infotext-wrap position--top horizonal--center \"> <div class=\"gem-infotext-icon\"> <div class=\"gem-icon gem-simple-icon gem-icon-use-image gem-icon-size-custom\"> <div class=\"gem-icon-inner\"><span class=\"gem-icon-half-1\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_005.png\" alt=\"Icone Alzheimer\"><\/span><\/span><span class=\"gem-icon-half-2\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_005.png\" alt=\"Icone Alzheimer\"><\/span><\/span><\/div> <\/div> <\/div> <div class=\"gem-infotext\"> <div class=\"gem-infotext__title\"> <div class=\"title-customize text-body\" style=\"text-align:center;\"> 60-70 % <\/div> <\/div> <div class=\"gem-infotext__subtitle\"> <div class=\"subtitle-customize text-body-tiny\" style=\"text-align:center;\"> des d\u00e9mences sont des maladies d\u2019Alzheimer <\/div> <\/div> <\/div> <\/div> <\/div>[\/vc_column_inner][vc_column_inner el_class=\u00a0\u00bbCUADROMINI\u00a0\u00bb width=\u00a0\u00bb7\/12&Prime; css=\u00a0\u00bb.vc_custom_1750756486329{padding-right: 5px !important;padding-bottom: 40px !important;padding-left: 5px !important;}\u00a0\u00bb offset=\u00a0\u00bbvc_col-lg-2 vc_col-md-2 vc_col-xs-7&Prime; mobile_padding_bottom=\u00a0\u00bb20&Prime; mobile_padding_left=\u00a0\u00bb10&Prime; mobile_padding_right=\u00a0\u00bb10&Prime;]<style>.thegem-custom-69f81ce0367cc2382 .gem-icon-half-1 {color: #00635F;}.thegem-custom-69f81ce0367cc2382 .gem-icon-half-2 {color: #00635F;}.thegem-custom-69f81ce0367cc2382 .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #00635F, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.thegem-custom-69f81ce0367cc2382 .gem-icon  {font-size: 77px;}.thegem-custom-69f81ce0367cc2382 .gem-icon:not(.gem-simple-icon) .gem-icon-inner {width: 115.5px; height: 115.5px; line-height: 115.5px;}.thegem-custom-69f81ce0367cc2382 .gem-icon.gem-simple-icon {width: 77px; height: 77px; line-height: 77px;}.thegem-custom-69f81ce0367cc2382 a:hover .gem-infotext-icon .gem-icon-half-1 {color: #EEEE22 !important;}.thegem-custom-69f81ce0367cc2382 a:hover .gem-infotext-icon .gem-icon-half-2 {color: #EEEE22 !important;}.thegem-custom-69f81ce0367cc2382 a:hover .gem-infotext-icon .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #EEEE22, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.gem-infotext.thegem-custom-69f81ce0367cc2382 .gem-infotext-icon {margin-top:-2px !important;}.gem-infotext.thegem-custom-69f81ce0367cc2382 .gem-infotext-icon {margin-right:0px !important;}.gem-infotext.thegem-custom-69f81ce0367cc2382 .title-customize {color:#FFFFFF !important;}.gem-infotext.thegem-custom-69f81ce0367cc2382 a:hover .gem-infotext .title-customize {color:#0D2E37 !important;}.gem-infotext.thegem-custom-69f81ce0367cc2382 .title-customize {margin-top:5px !important;}.gem-infotext.thegem-custom-69f81ce0367cc2382 .title-customize {margin-bottom:0px !important;}.gem-infotext.thegem-custom-69f81ce0367cc2382 .subtitle-customize {color:#000000 !important;}.gem-infotext.thegem-custom-69f81ce0367cc2382 .subtitle-customize {margin-top:0px !important;}.gem-infotext.thegem-custom-69f81ce0367cc2382 .subtitle-customize {margin-bottom:0px !important;}<\/style><div class=\"gem-infotext CAJADESIETE vc_custom_1752492826619 alignment-center thegem-custom-69f81ce0367cc2382\"> <div class=\"gem-infotext-wrap position--top horizonal--center \"> <div class=\"gem-infotext-icon\"> <div class=\"gem-icon gem-simple-icon gem-icon-use-image gem-icon-size-custom\"> <div class=\"gem-icon-inner\"><span class=\"gem-icon-half-1\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_006.png\" alt=\"Icone Coeur\"><\/span><\/span><span class=\"gem-icon-half-2\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_006.png\" alt=\"Icone Coeur\"><\/span><\/span><\/div> <\/div> <\/div> <div class=\"gem-infotext\"> <div class=\"gem-infotext__title\"> <div class=\"title-customize text-body\" style=\"text-align:center;\"> 2 Millions <\/div> <\/div> <div class=\"gem-infotext__subtitle\"> <div class=\"subtitle-customize text-body-tiny\" style=\"text-align:center;\"> Personnes aidantes <\/div> <\/div> <\/div> <\/div> <\/div>[\/vc_column_inner][vc_column_inner el_class=\u00a0\u00bbCUADROMINI\u00a0\u00bb width=\u00a0\u00bb7\/12&Prime; css=\u00a0\u00bb.vc_custom_1750756492730{padding-right: 5px !important;padding-bottom: 40px !important;padding-left: 5px !important;}\u00a0\u00bb offset=\u00a0\u00bbvc_col-lg-2 vc_col-md-2 vc_col-xs-6&Prime;]<style>.thegem-custom-69f81ce036a819625 .gem-icon-half-1 {color: #00635F;}.thegem-custom-69f81ce036a819625 .gem-icon-half-2 {color: #00635F;}.thegem-custom-69f81ce036a819625 .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #00635F, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.thegem-custom-69f81ce036a819625 .gem-icon  {font-size: 77px;}.thegem-custom-69f81ce036a819625 .gem-icon:not(.gem-simple-icon) .gem-icon-inner {width: 115.5px; height: 115.5px; line-height: 115.5px;}.thegem-custom-69f81ce036a819625 .gem-icon.gem-simple-icon {width: 77px; height: 77px; line-height: 77px;}.thegem-custom-69f81ce036a819625 a:hover .gem-infotext-icon .gem-icon-half-1 {color: #EEEE22 !important;}.thegem-custom-69f81ce036a819625 a:hover .gem-infotext-icon .gem-icon-half-2 {color: #EEEE22 !important;}.thegem-custom-69f81ce036a819625 a:hover .gem-infotext-icon .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #EEEE22, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.gem-infotext.thegem-custom-69f81ce036a819625 .gem-infotext-icon {margin-top:-2px !important;}.gem-infotext.thegem-custom-69f81ce036a819625 .gem-infotext-icon {margin-right:0px !important;}.gem-infotext.thegem-custom-69f81ce036a819625 .title-customize {color:#FFFFFF !important;}.gem-infotext.thegem-custom-69f81ce036a819625 a:hover .gem-infotext .title-customize {color:#0D2E37 !important;}.gem-infotext.thegem-custom-69f81ce036a819625 .title-customize {margin-top:5px !important;}.gem-infotext.thegem-custom-69f81ce036a819625 .title-customize {margin-bottom:0px !important;}.gem-infotext.thegem-custom-69f81ce036a819625 .subtitle-customize {color:#000000 !important;}.gem-infotext.thegem-custom-69f81ce036a819625 .subtitle-customize {margin-top:0px !important;}.gem-infotext.thegem-custom-69f81ce036a819625 .subtitle-customize {margin-bottom:0px !important;}<\/style><div class=\"gem-infotext CAJADESIETE vc_custom_1753089014770 alignment-center thegem-custom-69f81ce036a819625\"> <div class=\"gem-infotext-wrap position--top horizonal--center \"> <div class=\"gem-infotext-icon\"> <div class=\"gem-icon gem-simple-icon gem-icon-use-image gem-icon-size-custom\"> <div class=\"gem-icon-inner\"><span class=\"gem-icon-half-1\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_007.png\" alt=\"Icone Ensemble\"><\/span><\/span><span class=\"gem-icon-half-2\"><span class=\"back-angle\"><img class=\"img-responsive\" src=\"https:\/\/regenlife.com\/wp-content\/uploads\/2025\/07\/ICONO_CAJA_007.png\" alt=\"Icone Ensemble\"><\/span><\/span><\/div> <\/div> <\/div> <div class=\"gem-infotext\"> <div class=\"gem-infotext__title\"> <div class=\"title-customize text-body\" style=\"text-align:center;\"> 1 300 milliards de $ <\/div> <\/div> <div class=\"gem-infotext__subtitle\"> <div class=\"subtitle-customize text-body-tiny\" style=\"text-align:center;\"> Co\u00fbt mondial de la prise en charge des d\u00e9mences <\/div> <\/div> <\/div> <\/div> <\/div>[\/vc_column_inner][\/vc_row_inner][vc_row_inner equal_height=\u00a0\u00bbyes\u00a0\u00bb content_placement=\u00a0\u00bbmiddle\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1751013562826{margin-top: 0px !important;margin-bottom: 0px !important;padding-top: 0px !important;}\u00a0\u00bb tablet_padding_top=\u00a0\u00bb30&Prime; mobile_padding_top=\u00a0\u00bb50&Prime; mobile_padding_left=\u00a0\u00bb30&Prime; mobile_padding_right=\u00a0\u00bb0&Prime;][vc_column_inner width=\u00a0\u00bb5\/6&Prime; mobile_padding_bottom=\u00a0\u00bb70&Prime;]<style>.thegem-custom-69f81ce036d32797 .gem-icon-inner {background-color: #E0CCDC;}.thegem-custom-69f81ce036d32797 .gem-icon-half-1 {color: #AA689E;}.thegem-custom-69f81ce036d32797 .gem-icon-half-2 {color: #AA689E;}.thegem-custom-69f81ce036d32797 .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #AA689E, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.thegem-custom-69f81ce036d32797 .gem-icon  {border-color: #E0CCDC;border-color: #E0CCDC;}.thegem-custom-69f81ce036d32797 .gem-icon  {font-size: 22px;}.thegem-custom-69f81ce036d32797 .gem-icon:not(.gem-simple-icon) .gem-icon-inner {width: 33px; height: 33px; line-height: 33px;}.thegem-custom-69f81ce036d32797 .gem-icon.gem-simple-icon {width: 22px; height: 22px; line-height: 22px;}.gem-infotext.thegem-custom-69f81ce036d32797 .gem-infotext-icon {margin-top:-2px !important;}.gem-infotext.thegem-custom-69f81ce036d32797 .gem-infotext-icon {margin-right:20px !important;}.gem-infotext.thegem-custom-69f81ce036d32797 .title-customize {color:#62A9B4 !important;}.gem-infotext.thegem-custom-69f81ce036d32797 .title-customize {font-size:20px !important;}.gem-infotext.thegem-custom-69f81ce036d32797 .title-customize {letter-spacing:px !important;}.gem-infotext.thegem-custom-69f81ce036d32797 .title-customize {text-transform:none !important;}<\/style><div class=\"gem-infotext SUBRAYADO vc_custom_1753089152938 alignment-left thegem-custom-69f81ce036d32797\"> <a href=\"https:\/\/www.who.int\/fr\/news-room\/fact-sheets\/detail\/dementia\" target=\"_blank\" class=\"gem-infotext-wrap position--left vertical--center\" aria-label=\"Lire la suite\"> <div class=\"gem-infotext-icon\"> <div class=\"gem-icon gem-icon-pack-elegant gem-icon-size-custom gem-icon-shape-circle\"> <div class=\"gem-icon-inner\"><span class=\"gem-icon-half-1\"><span class=\"back-angle\">&#x4e;<\/span><\/span><span class=\"gem-icon-half-2\"><span class=\"back-angle\">&#x4e;<\/span><\/span><\/div> <\/div> <\/div> <div class=\"gem-infotext\"> <div class=\"gem-infotext__title\"> <div class=\"title-customize text-body\" style=\"\"> OMS, Dementia, mars 2025 <\/div> <\/div> <\/div> <\/a> <\/div><style>.thegem-custom-69f81ce036da76600 .gem-icon-inner {background-color: #E0CCDC;}.thegem-custom-69f81ce036da76600 .gem-icon-half-1 {color: #AA689E;}.thegem-custom-69f81ce036da76600 .gem-icon-half-2 {color: #AA689E;}.thegem-custom-69f81ce036da76600 .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #AA689E, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.thegem-custom-69f81ce036da76600 .gem-icon  {border-color: #E0CCDC;border-color: #E0CCDC;}.thegem-custom-69f81ce036da76600 .gem-icon  {font-size: 22px;}.thegem-custom-69f81ce036da76600 .gem-icon:not(.gem-simple-icon) .gem-icon-inner {width: 33px; height: 33px; line-height: 33px;}.thegem-custom-69f81ce036da76600 .gem-icon.gem-simple-icon {width: 22px; height: 22px; line-height: 22px;}.gem-infotext.thegem-custom-69f81ce036da76600 .gem-infotext-icon {margin-top:-2px !important;}.gem-infotext.thegem-custom-69f81ce036da76600 .gem-infotext-icon {margin-right:20px !important;}.gem-infotext.thegem-custom-69f81ce036da76600 .title-customize {color:#62A9B4 !important;}.gem-infotext.thegem-custom-69f81ce036da76600 .title-customize {font-size:20px !important;}.gem-infotext.thegem-custom-69f81ce036da76600 .title-customize {letter-spacing:px !important;}.gem-infotext.thegem-custom-69f81ce036da76600 .title-customize {text-transform:none !important;}<\/style><div class=\"gem-infotext SUBRAYADO vc_custom_1753089204031 alignment-left thegem-custom-69f81ce036da76600\"> <a href=\"https:\/\/www.frm.org\/fr\/alzheimer\" target=\"_blank\" class=\"gem-infotext-wrap position--left vertical--center\" aria-label=\"Lire la suite\"> <div class=\"gem-infotext-icon\"> <div class=\"gem-icon gem-icon-pack-elegant gem-icon-size-custom gem-icon-shape-circle\"> <div class=\"gem-icon-inner\"><span class=\"gem-icon-half-1\"><span class=\"back-angle\">&#x4e;<\/span><\/span><span class=\"gem-icon-half-2\"><span class=\"back-angle\">&#x4e;<\/span><\/span><\/div> <\/div> <\/div> <div class=\"gem-infotext\"> <div class=\"gem-infotext__title\"> <div class=\"title-customize text-body\" style=\"\"> Fondation pour la recherche m\u00e9dicale <\/div> <\/div> <\/div> <\/a> <\/div><style>.thegem-custom-69f81ce036e054051 .gem-icon-inner {background-color: #E0CCDC;}.thegem-custom-69f81ce036e054051 .gem-icon-half-1 {color: #AA689E;}.thegem-custom-69f81ce036e054051 .gem-icon-half-2 {color: #AA689E;}.thegem-custom-69f81ce036e054051 .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #AA689E, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.thegem-custom-69f81ce036e054051 .gem-icon  {border-color: #E0CCDC;border-color: #E0CCDC;}.thegem-custom-69f81ce036e054051 .gem-icon  {font-size: 22px;}.thegem-custom-69f81ce036e054051 .gem-icon:not(.gem-simple-icon) .gem-icon-inner {width: 33px; height: 33px; line-height: 33px;}.thegem-custom-69f81ce036e054051 .gem-icon.gem-simple-icon {width: 22px; height: 22px; line-height: 22px;}.gem-infotext.thegem-custom-69f81ce036e054051 .gem-infotext-icon {margin-top:-2px !important;}.gem-infotext.thegem-custom-69f81ce036e054051 .gem-infotext-icon {margin-right:20px !important;}.gem-infotext.thegem-custom-69f81ce036e054051 .title-customize {color:#62A9B4 !important;}.gem-infotext.thegem-custom-69f81ce036e054051 .title-customize {font-size:20px !important;}.gem-infotext.thegem-custom-69f81ce036e054051 .title-customize {letter-spacing:px !important;}.gem-infotext.thegem-custom-69f81ce036e054051 .title-customize {text-transform:none !important;}<\/style><div class=\"gem-infotext SUBRAYADO vc_custom_1753089234818 alignment-left thegem-custom-69f81ce036e054051\"> <a href=\"https:\/\/www.fondation-alzheimer.org\/\" target=\"_blank\" class=\"gem-infotext-wrap position--left vertical--center\" aria-label=\"Lire la suite\"> <div class=\"gem-infotext-icon\"> <div class=\"gem-icon gem-icon-pack-elegant gem-icon-size-custom gem-icon-shape-circle\"> <div class=\"gem-icon-inner\"><span class=\"gem-icon-half-1\"><span class=\"back-angle\">&#x4e;<\/span><\/span><span class=\"gem-icon-half-2\"><span class=\"back-angle\">&#x4e;<\/span><\/span><\/div> <\/div> <\/div> <div class=\"gem-infotext\"> <div class=\"gem-infotext__title\"> <div class=\"title-customize text-body\" style=\"\"> Fondation Alzheimer <\/div> <\/div> <\/div> <\/a> <\/div><style>.thegem-custom-69f81ce036e62105 .gem-icon-inner {background-color: #E0CCDC;}.thegem-custom-69f81ce036e62105 .gem-icon-half-1 {color: #AA689E;}.thegem-custom-69f81ce036e62105 .gem-icon-half-2 {color: #AA689E;}.thegem-custom-69f81ce036e62105 .gem-icon-style-gradient .back-angle {background: linear-gradient( to bottom, #AA689E, ); -webkit-text-fill-color: transparent; -webkit-background-clip: text;}.thegem-custom-69f81ce036e62105 .gem-icon  {border-color: #E0CCDC;border-color: #E0CCDC;}.thegem-custom-69f81ce036e62105 .gem-icon  {font-size: 22px;}.thegem-custom-69f81ce036e62105 .gem-icon:not(.gem-simple-icon) .gem-icon-inner {width: 33px; height: 33px; line-height: 33px;}.thegem-custom-69f81ce036e62105 .gem-icon.gem-simple-icon {width: 22px; height: 22px; line-height: 22px;}.gem-infotext.thegem-custom-69f81ce036e62105 .gem-infotext-icon {margin-top:-2px !important;}.gem-infotext.thegem-custom-69f81ce036e62105 .gem-infotext-icon {margin-right:20px !important;}.gem-infotext.thegem-custom-69f81ce036e62105 .title-customize {color:#62A9B4 !important;}.gem-infotext.thegem-custom-69f81ce036e62105 .title-customize {font-size:20px !important;}.gem-infotext.thegem-custom-69f81ce036e62105 .title-customize {letter-spacing:px !important;}.gem-infotext.thegem-custom-69f81ce036e62105 .title-customize {text-transform:none !important;}<\/style><div class=\"gem-infotext SUBRAYADO vc_custom_1753089261431 alignment-left thegem-custom-69f81ce036e62105\"> <a href=\"https:\/\/www.fondation-mederic-alzheimer.org\/\" target=\"_blank\" class=\"gem-infotext-wrap position--left vertical--center\" aria-label=\"Lire la suite\"> <div class=\"gem-infotext-icon\"> <div class=\"gem-icon gem-icon-pack-elegant gem-icon-size-custom gem-icon-shape-circle\"> <div class=\"gem-icon-inner\"><span class=\"gem-icon-half-1\"><span class=\"back-angle\">&#x4e;<\/span><\/span><span class=\"gem-icon-half-2\"><span class=\"back-angle\">&#x4e;<\/span><\/span><\/div> <\/div> <\/div> <div class=\"gem-infotext\"> <div class=\"gem-infotext__title\"> <div class=\"title-customize text-body\" style=\"\"> Fondation M\u00e9d\u00e9ric Alzheimer <\/div> <\/div> <\/div> <\/a> <\/div>[\/vc_column_inner][vc_column_inner width=\u00a0\u00bb1\/6&Prime; css=\u00a0\u00bb.vc_custom_1750770358477{margin-left: -33px !important;}\u00a0\u00bb][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=\u00a0\u00bbstretch_row\u00a0\u00bb custom_css_code=\u00a0\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\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1750770866069{margin-bottom: 0px !important;}\u00a0\u00bb][vc_column css=\u00a0\u00bb.vc_custom_1726578677849{padding-top: 0px !important;}\u00a0\u00bb][vc_row_inner css=\u00a0\u00bb.vc_custom_1751013679067{margin-right: 90px !important;margin-left: 90px !important;background-color: #D8BED3 !important;border-radius: 25px !important;}\u00a0\u00bb el_class=\u00a0\u00bbCONTENEDORAVISO\u00a0\u00bb mobile_margin_left=\u00a0\u00bb10&Prime; mobile_margin_right=\u00a0\u00bb10&Prime;][vc_column_inner][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<h4 style=\"text-align: center;\"><strong>En 2023, REGEnLIFE a lanc\u00e9, avec le G\u00e9rontop<\/strong><strong>\u00f4le du CHU de Toulouse, un essai clinique pivot sur la maladie d\u2019Alzheimer (<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05926011\" target=\"_blank\" rel=\"noopener\">LIGHT4LIFE<\/a>) <\/strong>\u00a0<strong>pour confirmer l\u2019efficacit\u00e9 de sa technologie sur une plus longue p\u00e9riode de temps et sur un plus grand nombre de patients. Les premiers r\u00e9sultats sont attendus pour fin 2026.\u00a0<\/strong><\/h4>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=\u00a0\u00bbstretch_row\u00a0\u00bb custom_css_code=\u00a0\u00bbLmN1c3RvbS10aXRsZSUyMGgyJTdCJTBBJTIwJTIwJTIwJTIwbWFyZ2luLXJpZ2h0JTNBJTIwMzBweCUyMWltcG9ydGFudCUzQiUwQSUyMCUyMCUyMCUyMG1hcmdpbi1ib3R0b20lM0ElMjAwJTIxaW1wb3J0YW50JTNCJTBBJTIwJTIwJTIwJTIwbWFyZ2luLXRvcCUzQSUyMDAlMjFpbXBvcnRhbnQlM0IlMEElN0QlMEEuY3VzdG9tLXRpdGxlJTIwLnZjX3NlcF9saW5lJTIwJTdCJTBBJTIwJTIwJTIwJTIwdG9wJTNBJTIwMTJweCUyMWltcG9ydGFudCUzQiUwQSU3RCUwQS5nZW0taW5mb3RleHQlMjAlN0IlMEElMjAlMjAlMjAlMjB3aWR0aCUzQSUyMGF1dG8lMjFpbXBvcnRhbnQlM0IlMEElN0QlMEEuZ2VtLWluZm90ZXh0JTNBaG92ZXIlMjAlN0IlMEElMjAlMjAlMjAlMjBiYWNrZ3JvdW5kLWNvbG9yJTNBJTIwJTIzRjlFQUQ1JTIwJTIxaW1wb3J0YW50JTNCJTBBJTIwJTIwJTIwJTIwdHJhbnNpdGlvbiUzQSUyMGFsbCUyMDAuM3MlM0IlMEElN0QlMEE=\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1750770873932{margin-bottom: 0px !important;padding-top: 80px !important;}\u00a0\u00bb][vc_column css=\u00a0\u00bb.vc_custom_1726578677849{padding-top: 0px !important;}\u00a0\u00bb][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><span style=\"color: #6dadb6;\">Pr\u00e9sentation des travaux en cours \u202fpour chaque indication : <\/span><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=\u00a0\u00bbstretch_row\u00a0\u00bb gap=\u00a0\u00bb10&Prime; equal_height=\u00a0\u00bbyes\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1751623680897{margin-bottom: 0px !important;}\u00a0\u00bb][vc_column width=\u00a0\u00bb1\/3&Prime; css=\u00a0\u00bb.vc_custom_1753876420294{border-top-width: 2px !important;border-right-width: 2px !important;border-bottom-width: 2px !important;border-left-width: 2px !important;padding-top: 35px !important;padding-right: 21px !important;padding-bottom: 50px !important;padding-left: 21px !important;border-left-style: solid !important;border-right-style: solid !important;border-top-style: solid !important;border-bottom-style: solid !important;border-radius: 30px !important;border-color: #DBE7E6 !important;}\u00a0\u00bb mobile_padding_bottom=\u00a0\u00bb20&Prime;][vc_single_image image=\u00a0\u00bb4229&Prime; img_size=\u00a0\u00bb150&#215;150&Prime; css=\u00a0\u00bb.vc_custom_1752654287133{margin-bottom: 0px !important;margin-left: 0px !important;}\u00a0\u00bb][vc_column_text css=\u00a0\u00bb.vc_custom_1753089599267{margin-bottom: 20px !important;}\u00a0\u00bb]<\/p>\n<h5><span style=\"color: #af6ba3;\">L\u2019<strong>\u0415ssai clinique pivot <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05926011\" target=\"_blank\" rel=\"noopener\">LIGHT4LIFE<\/a><\/strong><strong> (NCT05926011) : en cours pour \u00e9valuer la technologie REGEnLIFE sur des patients atteints de maladie d\u2019<\/strong><strong>Alzheimer<\/strong><\/span><\/h5>\n<p>[\/vc_column_text][vc_column_text css=\u00a0\u00bb.vc_custom_1753089632036{margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;border-left-width: 0px !important;padding-right: 0px !important;}\u00a0\u00bb]Le RGn600, une nouvelle version de la technologie REGEnLIFE est en cours d\u2019\u00e9valuation dans un essai clinique multicentrique en double-aveugle randomis\u00e9 en partenariat avec le G\u00e9rontop\u00f4le du CHU de Toulouse et d\u2019autres centres investigateurs.[\/vc_column_text][\/vc_column][vc_column width=\u00a0\u00bb1\/3&Prime; css=\u00a0\u00bb.vc_custom_1753876492577{border-top-width: 2px !important;border-right-width: 2px !important;border-bottom-width: 2px !important;border-left-width: 2px !important;padding-top: 35px !important;padding-right: 21px !important;padding-bottom: 20px !important;padding-left: 21px !important;border-left-style: solid !important;border-right-style: solid !important;border-top-style: solid !important;border-bottom-style: solid !important;border-radius: 30px !important;border-color: #DBE7E6 !important;}\u00a0\u00bb mobile_padding_bottom=\u00a0\u00bb20&Prime;][vc_single_image image=\u00a0\u00bb4235&Prime; img_size=\u00a0\u00bb150&#215;150&Prime; css=\u00a0\u00bb.vc_custom_1752654299039{margin-bottom: 0px !important;margin-left: 0px !important;}\u00a0\u00bb][vc_column_text css=\u00a0\u00bb.vc_custom_1753089678374{margin-bottom: 20px !important;}\u00a0\u00bb]<\/p>\n<h5><span style=\"color: #af6ba3;\">E<strong>ssai clinique pilote de la technologie photom\u00e9<\/strong><strong>dicale de REGEnLIFE d<\/strong><strong>\u00e9di<\/strong><strong>\u00e9e au traitement de la maladie d\u2019<\/strong><strong>Alzheimer<\/strong><\/span><\/h5>\n<p>[\/vc_column_text][vc_column_text css=\u00a0\u00bb.vc_custom_1750771049887{margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;border-left-width: 0px !important;padding-right: 0px !important;}\u00a0\u00bb]Le RGn s&rsquo;est montr\u00e9 s\u00fbr et bien tol\u00e9r\u00e9 dans une \u00e9tude clinique pilote sur la maladie d&rsquo;Alzheimer.[\/vc_column_text][\/vc_column][vc_column width=\u00a0\u00bb1\/3&Prime; css=\u00a0\u00bb.vc_custom_1753876512392{border-top-width: 2px !important;border-right-width: 2px !important;border-bottom-width: 2px !important;border-left-width: 2px !important;padding-top: 35px !important;padding-right: 21px !important;padding-bottom: 20px !important;padding-left: 21px !important;border-left-style: solid !important;border-right-style: solid !important;border-top-style: solid !important;border-bottom-style: solid !important;border-radius: 30px !important;border-color: #DBE7E6 !important;}\u00a0\u00bb][vc_single_image image=\u00a0\u00bb4236&Prime; img_size=\u00a0\u00bb150&#215;150&Prime; css=\u00a0\u00bb.vc_custom_1752654311764{margin-bottom: 0px !important;margin-left: 0px !important;}\u00a0\u00bb][vc_column_text css=\u00a0\u00bb.vc_custom_1753089851965{margin-bottom: 20px !important;}\u00a0\u00bb]<\/p>\n<h5><span style=\"color: #af6ba3;\"><strong>\u00c9tudes pr\u00e9cliniques r\u00e9alis<\/strong><strong>\u00e9es par REGEnLIFE<\/strong><\/span><\/h5>\n<p>[\/vc_column_text][vc_column_text css=\u00a0\u00bb.vc_custom_1753089888417{margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;border-left-width: 0px !important;padding-right: 0px !important;}\u00a0\u00bb]Dans les \u00e9tudes pr\u00e9cliniques, le prototype RGn500 a montr\u00e9 son efficacit\u00e9 pour normaliser les d\u00e9ficits de m\u00e9moire et les changements biochimiques dans le mod\u00e8le murin A\u03b225-35, imitant les caract\u00e9ristiques pathologiques de la maladie d\u2019Alzheimer.[\/vc_column_text][vc_row_inner el_disable_desktop=\u00a0\u00bb1&Prime; el_disable_tablet=\u00a0\u00bb1&Prime; mobile_padding_top=\u00a0\u00bb33&Prime; el_id=\u00a0\u00bbMOVILES\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1751391009028{padding-left: 12px !important;}\u00a0\u00bb][vc_column_inner]<style type=\"text\/css\">.thegem-button-69f81ce036ed763 .gem-button {font-size: 22px;padding-left: 20px;padding-right: 12px;margin-top: 0px;}@media (max-width: 767px) {.thegem-button-69f81ce036ed763 .gem-button {padding-left: 25px;}}.thegem-button-69f81ce036ed763 .gem-button svg {fill: #000000;}.thegem-button-69f81ce036ed763 .gem-button:hover svg {fill: #FFFFFF;}<\/style><div class=\"gem-button-container gem-button-position-inline thegem-button-69f81ce036ed763 custom-button-seo-agency   \"  ><a class=\"gem-button gem-button-size-tiny gem-button-style-outline gem-button-text-weight-thin gem-button-border-2 gem-button-no-uppercase\" data-ll-effect=\"drop-right-without-wrap\" style=\"border-radius: 100px;border-color: #000000;color: #000000;\" onmouseleave=\"this.style.borderColor='#000000';this.style.backgroundColor='transparent';this.style.color='#000000';\" onmouseenter=\"this.style.backgroundColor='#000000';this.style.color='#FFFFFF';\" href=\"\" target=\"_self\" role=\"button\">En savoir plus<\/a><\/div> [\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=\u00a0\u00bbstretch_row\u00a0\u00bb gap=\u00a0\u00bb10&Prime; content_placement=\u00a0\u00bbtop\u00a0\u00bb el_disable_mobile=\u00a0\u00bb1&Prime; css=\u00a0\u00bb.vc_custom_1751623655023{margin-bottom: 0px !important;}\u00a0\u00bb el_id=\u00a0\u00bbDESKTOP\u00a0\u00bb][vc_column width=\u00a0\u00bb1\/3&Prime; css=\u00a0\u00bb.vc_custom_1751363825223{margin-top: 0px !important;margin-bottom: 0px !important;padding-top: 21px !important;padding-right: 21px !important;padding-left: 21px !important;border-radius: 30px !important;border-color: #DBE7E6 !important;}\u00a0\u00bb mobile_padding_bottom=\u00a0\u00bb20&Prime;]<style type=\"text\/css\">.thegem-button-69f81ce036f42302 .gem-button {font-size: 22px;padding-left: 20px;padding-right: 12px;margin-top: 0px;}@media (max-width: 767px) {.thegem-button-69f81ce036f42302 .gem-button {padding-left: 25px;}}.thegem-button-69f81ce036f42302 .gem-button svg {fill: #000000;}.thegem-button-69f81ce036f42302 .gem-button:hover svg {fill: #FFFFFF;}<\/style><div class=\"gem-button-container gem-button-position-inline thegem-button-69f81ce036f42302 custom-button-seo-agency   \"  ><a class=\"gem-button gem-button-size-tiny gem-button-style-outline gem-button-text-weight-thin gem-button-border-2 gem-button-no-uppercase\" data-ll-effect=\"drop-right-without-wrap\" style=\"border-radius: 100px;border-color: #000000;color: #000000;\" onmouseleave=\"this.style.borderColor='#000000';this.style.backgroundColor='transparent';this.style.color='#000000';\" onmouseenter=\"this.style.backgroundColor='#000000';this.style.color='#FFFFFF';\" href=\"https:\/\/regenlife.com\/alzheimer-essai-clinique\/#light4life\" target=\"_self\">En savoir plus<\/a><\/div> [\/vc_column][vc_column width=\u00a0\u00bb1\/3&Prime; css=\u00a0\u00bb.vc_custom_1751363998950{margin-top: 0px !important;margin-bottom: 0px !important;padding-top: 21px !important;padding-right: 21px !important;padding-left: 21px !important;border-radius: 30px !important;border-color: #DBE7E6 !important;}\u00a0\u00bb mobile_padding_bottom=\u00a0\u00bb20&Prime;]<style type=\"text\/css\">.thegem-button-69f81ce036f8e1090 .gem-button {font-size: 22px;padding-left: 20px;padding-right: 12px;margin-top: 0px;}@media (max-width: 767px) {.thegem-button-69f81ce036f8e1090 .gem-button {padding-left: 25px;}}.thegem-button-69f81ce036f8e1090 .gem-button svg {fill: #000000;}.thegem-button-69f81ce036f8e1090 .gem-button:hover svg {fill: #FFFFFF;}<\/style><div class=\"gem-button-container gem-button-position-inline thegem-button-69f81ce036f8e1090 custom-button-seo-agency   \"  ><a class=\"gem-button gem-button-size-tiny gem-button-style-outline gem-button-text-weight-thin gem-button-border-2 gem-button-no-uppercase\" data-ll-effect=\"drop-right-without-wrap\" style=\"border-radius: 100px;border-color: #000000;color: #000000;\" onmouseleave=\"this.style.borderColor='#000000';this.style.backgroundColor='transparent';this.style.color='#000000';\" onmouseenter=\"this.style.backgroundColor='#000000';this.style.color='#FFFFFF';\" href=\"https:\/\/regenlife.com\/alzheimer-essai-clinique\/#pilote\" target=\"_self\">En savoir plus<\/a><\/div> [\/vc_column][vc_column width=\u00a0\u00bb1\/3&Prime; css=\u00a0\u00bb.vc_custom_1751364008635{margin-top: 0px !important;margin-bottom: 0px !important;padding-top: 21px !important;padding-right: 21px !important;padding-left: 21px !important;border-radius: 30px !important;border-color: #DBE7E6 !important;}\u00a0\u00bb]<style type=\"text\/css\">.thegem-button-69f81ce036fd43785 .gem-button {font-size: 22px;padding-left: 20px;padding-right: 12px;margin-top: 0px;}@media (max-width: 767px) {.thegem-button-69f81ce036fd43785 .gem-button {padding-left: 25px;}}.thegem-button-69f81ce036fd43785 .gem-button svg {fill: #000000;}.thegem-button-69f81ce036fd43785 .gem-button:hover svg {fill: #FFFFFF;}<\/style><div class=\"gem-button-container gem-button-position-inline thegem-button-69f81ce036fd43785 custom-button-seo-agency   \"  ><a class=\"gem-button gem-button-size-tiny gem-button-style-outline gem-button-text-weight-thin gem-button-border-2 gem-button-no-uppercase\" data-ll-effect=\"drop-right-without-wrap\" style=\"border-radius: 100px;border-color: #000000;color: #000000;\" onmouseleave=\"this.style.borderColor='#000000';this.style.backgroundColor='transparent';this.style.color='#000000';\" onmouseenter=\"this.style.backgroundColor='#000000';this.style.color='#FFFFFF';\" href=\"https:\/\/regenlife.com\/alzheimer-essai-clinique\/#precliniques\" target=\"_self\">En savoir plus<\/a><\/div> [\/vc_column][\/vc_row][vc_row][vc_column]<div class=\"clearboth\"><\/div><style>#thegem-divider-69f81ce037001 {margin-top: 50px !important;}<\/style><div id=\"thegem-divider-69f81ce037001\" class=\"gem-divider  \" style=\"\" ><\/div>[\/vc_column][\/vc_row][vc_row full_width=\u00a0\u00bbstretch_row\u00a0\u00bb custom_css_code=\u00a0\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\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1753876454681{margin-bottom: 0px !important;padding-top: 85px !important;padding-bottom: 85px !important;background-color: #FFFFFF !important;}\u00a0\u00bb el_id=\u00a0\u00bblight4life\u00a0\u00bb][vc_column css=\u00a0\u00bb.vc_custom_1726578677849{padding-top: 0px !important;}\u00a0\u00bb][vc_row_inner content_placement=\u00a0\u00bbbottom\u00a0\u00bb][vc_column_inner][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<h4 style=\"text-align: left;\"><span style=\"color: #69abb4;\"><strong><span style=\"color: #aa689e;\">L\u2019\u0415ssai clinique pivot Light4Life : en cours pour \u00e9valuer la technologie REGEnLIFE sur des patients atteints de maladie d\u2019Alzheimer<\/span><\/strong><\/span><\/h4>\n<p>[\/vc_column_text][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<p align=\"justify\"><strong>Le RGn600, une nouvelle version de la technologie REGEnLIFE est en cours d\u2019\u00e9valuation dans un essai clinique multicentrique en double-aveugle randomis\u00e9 en partenariat avec le G\u00e9rontop\u00f4le du CHU de Toulouse et d\u2019autres centres investigateurs.<\/strong><\/p>\n<p align=\"justify\"><strong>Contexte<\/strong><\/p>\n<p align=\"justify\">La maladie d&rsquo;Alzheimer (MA) repr\u00e9sente un grave probl\u00e8me de sant\u00e9 publique, pour lequel aucun traitement clairement efficace n&rsquo;est actuellement disponible.<\/p>\n<p align=\"justify\">Le \u00ab\u00a0REGEnLIFE RGn600\u00a0\u00bb est un dispositif m\u00e9dical de photobiomodulation (PBM) ciblant le cerveau et l\u2019intestin. Les r\u00e9sultats d&rsquo;un premier essai clinique pilote ont d\u00e9montr\u00e9 l&rsquo;innocuit\u00e9 et l&rsquo;observance des patients et ont r\u00e9v\u00e9l\u00e9 des tendances d&rsquo;efficacit\u00e9 chez 53 patients atteints de la maladie d&rsquo;Alzheimer l\u00e9g\u00e8re \u00e0 mod\u00e9r\u00e9e trait\u00e9s avec la th\u00e9rapie PBM (Blivet et al.,\u00a0A randomized, double-blind, and sham-controlled trial of an innovative brain-gut photobiomodulation therapy : safety and patient compliance. J Alzheimer&rsquo;s Dis. 2022, 90 : 2). Cette \u00e9tude a fourni\u00a0des informations pr\u00e9cieuses pour\u00a0la conception de notre essai th\u00e9rapeutique pivot, qui \u00e9value\u00a0actuellement les avantages cognitifs de la th\u00e9rapie par photobiomodulation, dans un \u00e9chantillon plus large de patients atteints de la maladie d&rsquo;Alzheimer.<\/p>\n<p align=\"justify\"><strong>Objectifs<\/strong><\/p>\n<p align=\"justify\">Le crit\u00e8re d&rsquo;\u00e9valuation principal de cet essai clinique pivot est l&rsquo;\u00e9volution de la cognition des patients apr\u00e8s 26 semaines de th\u00e9rapie PBM, mesur\u00e9e par le score ADAS-cog. Les fonctions neuropsychologiques, l&rsquo;autonomie, la r\u00e9ponse clinique globale, la qualit\u00e9 de vie, les marqueurs sanguins et f\u00e9caux ainsi que l&rsquo;int\u00e9r\u00eat m\u00e9dico-\u00e9conomique sont \u00e9tudi\u00e9s comme crit\u00e8res secondaires. La s\u00e9curit\u00e9 du traitement RGn600 est \u00e9galement \u00e9valu\u00e9e.<\/p>\n<p align=\"justify\"><strong>M\u00e9thodes<\/strong><\/p>\n<p align=\"justify\">Le RGn600 est un dispositif m\u00e9dical non invasif, fabriqu\u00e9 par REGEnLIFE, qui se pr\u00e9sente sous la forme d&rsquo;un casque et d&rsquo;une ceinture abdominale combinant la technologie PBM des longueurs d&rsquo;onde rouge \u00e0 proche infrarouge et la stimulation magn\u00e9tique statique.<\/p>\n<p align=\"justify\">Un essai clinique pivot multicentrique, en double aveugle, randomis\u00e9, contr\u00f4l\u00e9\u00a0a \u00e9t\u00e9 initi\u00e9 en juillet 2023 au G\u00e9rontopole du CHU de Toulouse. Au total, 108 patients pr\u00e9sentant les crit\u00e8res de diagnostic NIA-AA de la MA seront inclus et randomis\u00e9s en un groupe trait\u00e9 (n=54) et un groupe sham (n=54). Ils recevront 84 s\u00e9ances de th\u00e9rapie PBM de 20 min sur 26 semaines.<\/p>\n<p align=\"justify\"><strong>R\u00e9sultats<\/strong><\/p>\n<p align=\"justify\">La premi\u00e8re visite du premier patient a eu lieu\u00a0en juillet 2023.\u00a0L&rsquo;analyse statistique sera effectu\u00e9e dans l&rsquo;ensemble d&rsquo;analyse complet, les populations per protocole et l&rsquo;ensemble trait\u00e9.<\/p>\n<p align=\"justify\"><strong>Conclusion<\/strong><\/p>\n<p align=\"justify\">La th\u00e9rapie PBM cerveau-intestin REGEnLIFE RGn600, en tant que traitement, pourrait potentiellement offrir une m\u00e9thode s\u00fbre, bien tol\u00e9r\u00e9e, avec des avantages m\u00e9dicaux et \u00e9conomiques, pour traiter les patients atteints de MA l\u00e9g\u00e8re \u00e0 mod\u00e9r\u00e9e. La conception de cette \u00e9tude, nomm\u00e9e LIGHT4LIFE, \u00e9valuant un tel dispositif m\u00e9dical innovant pour le traitement de la MA est d\u00e9taill\u00e9e (<a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05926011\">NCT05926011<\/a>). Les avantages et les limites de cet essai clinique seront discut\u00e9s.<\/p>\n<p align=\"justify\"><strong>Sites investigateurs de l\u2019essai clinique Light4Life :<\/strong><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner css=\u00a0\u00bb.vc_custom_1762866166533{margin-top: -20px !important;}\u00a0\u00bb][vc_column_inner width=\u00a0\u00bb1\/3&Prime;][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<strong>Castres, France, 81100<\/strong><br \/>\nRecrutement patients en cours<br \/>\nCHIC Castres Mazamet Site Autan<br \/>\nContact :<br \/>\nMarie-No\u00eblle Cufi, Geriatrician<br \/>\n<a href=\"mailto:marie-noelle.cufi@chic-cm.fr\">marie-noelle.cufi@chic-cm.fr<\/a>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=\u00a0\u00bb1\/3&Prime;][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<strong>Lavaur, France, 81500<\/strong><br \/>\nRecrutement patients en cours<br \/>\nCH Lavaur<br \/>\nContact :<br \/>\nC\u00e9line Guillemaud, Geriatrician<br \/>\n<a href=\"mailto:c.guillemaud@ch-lavaur.fr\">c.guillemaud@ch-lavaur.fr<\/a>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=\u00a0\u00bb1\/3&Prime;][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<strong>Paris, France, 75010<\/strong><br \/>\nRecrutement patients en cours<br \/>\nH\u00f4pital Lariboisi\u00e8re, AP-HP<br \/>\nContact :<br \/>\nClaire PAQUET, Neurologist<br \/>\n<a href=\"mailto:claire.paquet@aphp.fr\">claire.paquet@aphp.fr<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner css=\u00a0\u00bb.vc_custom_1762866073170{margin-top: -20px !important;}\u00a0\u00bb][vc_column_inner width=\u00a0\u00bb1\/3&Prime;][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<strong>Paris, France, 75013<\/strong><br \/>\nRecrutement patients en cours<br \/>\nH\u00f4pital Broca, AP-HP<br \/>\nContact :<br \/>\nMarie Laure SEUX, Geriatrician<br \/>\n<a href=\"mailto:marie-laure.seux@aphp.fr\">marie-laure.seux@aphp.fr<\/a>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=\u00a0\u00bb1\/3&Prime;][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<strong>Toulouse, France, 31 000<\/strong><br \/>\nRecrutement patients en cours<br \/>\nCHU de Toulouse-Gerontopole<br \/>\nContact :<br \/>\nJulien DELRIEU, Neurologist-Geriatrician +33 5 61 77 70 58<br \/>\n<a href=\"mailto:delrieu.j@chu-toulouse.fr\">delrieu.j@chu-toulouse.fr<\/a>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=\u00a0\u00bb1\/3&Prime;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row css=\u00a0\u00bb.vc_custom_1753876695110{padding-top: 85px !important;padding-bottom: 85px !important;}\u00a0\u00bb el_id=\u00a0\u00bbpilote\u00a0\u00bb][vc_column][vc_row_inner content_placement=\u00a0\u00bbbottom\u00a0\u00bb][vc_column_inner][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<h4 style=\"text-align: left;\"><span style=\"color: #69abb4;\"><strong><span style=\"color: #aa689e;\">Essai clinique pilote de la technologie photom\u00e9dicale de REGEnLIFE d\u00e9di\u00e9e au traitement de la maladie d\u2019Alzheimer<\/span><\/strong><\/span><\/h4>\n<p>[\/vc_column_text][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<p align=\"justify\"><strong>Le RGn s&rsquo;est montr\u00e9 s\u00fbr et bien tol\u00e9r\u00e9 dans une \u00e9tude clinique pilote sur la maladie d&rsquo;Alzheimer.<\/strong><\/p>\n<p align=\"justify\">REGEnLIFE a annonc\u00e9, en mars 2021, les premiers r\u00e9sultats encourageants de sa premi\u00e8re \u00e9tude clinique pilote \u00e9valuant son dispositif m\u00e9dical sur la maladie d\u2019Alzheimer. Ils ont \u00e9t\u00e9 pr\u00e9sent\u00e9s lors de la 15e Conf\u00e9rence internationale sur les maladies d\u2019Alzheimer et de Parkinson (AD\/PD 2021) du 9 au 14 mars dernier, par le Professeur Jacques Touchon, conseiller scientifique sur cet essai clinique.<\/p>\n<p align=\"justify\">La technologie novatrice et non-invasive de REGEnLIFE, qui fait l\u2019objet de cet essai th\u00e9rapeutique, repose sur une technique de photobiomodulation visant \u00e0 cibler le cerveau et l\u2019intestin, gr\u00e2ce \u00e0 un casque et un plastron abdominal. Ce dispositif m\u00e9dical in\u00e9dit en photo-m\u00e9decine, baptis\u00e9 RGn, a pour objectif de stimuler les cellules dans le cerveau et l\u2019intestin et de r\u00e9guler l\u2019inflammation, de mani\u00e8re \u00e0 am\u00e9liorer le fonctionnement cognitif et le comportement. Il cible ainsi l\u2019inflammation sur l\u2019axe cerveau-intestin, qui serait impliqu\u00e9 dans le d\u00e9veloppement de la maladie d\u2019Alzheimer ou d\u2019autres affections neurologiques.<\/p>\n<p align=\"justify\"><span style=\"color: #69abb4;\"><strong>Design de l\u2019\u00e9tude clinique pilote de REGEnLIFE sur la maladie d\u2019Alzheimer\u00a0:<\/strong><\/span><\/p>\n<p align=\"justify\">\u00c9tude pilote \u00e9valuant la s\u00e9curit\u00e9 et l&rsquo;efficacit\u00e9 d&rsquo;un prototype de photobiomodulation, RGn, d\u00e9velopp\u00e9 par la soci\u00e9t\u00e9 REGEnLIFE sur l&rsquo;\u00e9volution des performances cognitives chez les patients atteints de la maladie d&rsquo;Alzheimer l\u00e9g\u00e8re \u00e0 mod\u00e9r\u00e9e.\u00a0<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03672474\">(NCT03672474)<\/a><\/p>\n<p>[\/vc_column_text][vc_single_image image=\u00a0\u00bb4652&Prime; img_size=\u00a0\u00bblarge\u00a0\u00bb alignment=\u00a0\u00bbcenter\u00a0\u00bb css=\u00a0\u00bb\u00a0\u00bb][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<p align=\"justify\">Cet essai a port\u00e9 sur des volontaires adultes, \u00e2g\u00e9s de 55 \u00e0 85 ans, atteints, \u00e0 un stade l\u00e9ger \u00e0 mod\u00e9r\u00e9 de la maladie d\u2019Alzheimer. \u00c9quip\u00e9s d\u2019un casque et d\u2019une ceinture abdominale de photobiomodulation, ces patients ont b\u00e9n\u00e9fici\u00e9 de 40 s\u00e9ances de 25 minutes r\u00e9parties sur deux mois et ont \u00e9t\u00e9 \u00e9valu\u00e9s par un ensemble de tests le long de l\u2019\u00e9tude et jusqu\u2019\u00e0 un mois apr\u00e8s l\u2019arr\u00eat du traitement. Cet essai clinique en double aveugle, randomis\u00e9, monocentrique et contr\u00f4l\u00e9 par placebo, a d\u00e9but\u00e9 en 2018 et s&rsquo;est termin\u00e9 pr\u00e9matur\u00e9ment en 2020 en raison de la pand\u00e9mie de COVID-19. Sur les 64 pr\u00e9vus, 53 patients ont \u00e9t\u00e9 randomis\u00e9s en deux groupes (trait\u00e9s et placebo) et 43 patients ont pu b\u00e9n\u00e9ficier du traitement pendant la dur\u00e9e pr\u00e9vue.<\/p>\n<ul>\n<li>Le groupe trait\u00e9 montre des tendances en faveur d\u2019une am\u00e9lioration cognitive, des fonctions ex\u00e9cutives, de la compr\u00e9hension du langage et de la m\u00e9moire verbale par rapport au groupe placebo<\/li>\n<li>La technologie de REGEnLIFE s\u2019est montr\u00e9e s\u00fbre et bien tol\u00e9r\u00e9e par les patients trait\u00e9s<\/li>\n<li>Ces r\u00e9sultats ouvrent de nouvelles perspectives pour le d\u00e9veloppement de ce dispositif in\u00e9dit pour la pr\u00e9vention et le traitement des affections neurologiques par une stimulation \u00e0 la fois c\u00e9r\u00e9brale et intestinale<\/li>\n<\/ul>\n<p align=\"justify\">Le crit\u00e8re principal d\u2019efficacit\u00e9 \u00e9tait mesur\u00e9 par l&rsquo;\u00e9volution du score total de l\u2019ADAS-Cog (Alzheimer\u2019s Disease Assessment Scale) entre l&rsquo;inclusion et les deux mois de traitement. En termes de s\u00e9curit\u00e9 d\u2019usage, le dispositif REGEnLIFE RGn\u00a0s\u2019est av\u00e9r\u00e9 s\u00fbr et aucun effet ind\u00e9sirable grave n&rsquo;a \u00e9t\u00e9 signal\u00e9. L&rsquo;observance des s\u00e9ances de traitement \u00e9tait tr\u00e8s bonne pour une grande majorit\u00e9 des patients 92 %), et a pu \u00e9galement confirmer la bonne tol\u00e9rance du dispositif. Si le crit\u00e8re principal d&rsquo;efficacit\u00e9 n&rsquo;a pas \u00e9t\u00e9 atteint en termes statistiques, une tendance est claire quant \u00e0 l\u2019am\u00e9lioration d\u2019un ensemble de fonctions cognitives. Les r\u00e9sultats de cette \u00e9tude pilote ont montr\u00e9 que la technologie REGEnLIFE est s\u00fbre et bien tol\u00e9r\u00e9e par les patients. Ces r\u00e9sultats tr\u00e8s encourageants de s\u00e9curit\u00e9 et d&rsquo;efficacit\u00e9 doivent \u00eatre confirm\u00e9s dans un essai clinique pivot ou phase III.<\/p>\n<p align=\"justify\">\u00ab\u00a0La strat\u00e9gie th\u00e9rapeutique de la maladie d\u2019Alzheimer, pour \u00eatre efficace, devra int\u00e9resser plusieurs cibles. Les traitements m\u00e9dicamenteux visant les deux prot\u00e9ines caract\u00e9ristiques du processus Alzheimer (prot\u00e9ines b\u00eata-amylo\u00efde et tau) doivent \u00eatre compl\u00e9t\u00e9es par d\u2019autres th\u00e9rapeutiques visant des m\u00e9canismes moins sp\u00e9cifiques mais tr\u00e8s importants dans la cascade physiopathologique telle que l\u2019inflammation et le stress oxydant. La technologie de photobiomodulation d\u00e9velopp\u00e9e par REGEnLIFE agit tr\u00e8s en amont sur cette cascade (mitochondrie, inflammation, stress oxydant). Elle pourrait \u00eatre le compl\u00e9ment non-m\u00e9dicamenteux de la strat\u00e9gie th\u00e9rapeutique du futur. La technologie de REGEnLIFE permet, en outre, d\u2019agir \u00e0 la fois sur le cerveau et l\u2019intestin, atout non n\u00e9gligeable quand on sait l\u2019importance du r\u00f4le de l\u2019axe cerveau-intestin et du microbiote dans les affections neurologiques\u00a0\u00bb, ajoute le Professeur Jacques Touchon, neurologue et psychiatre, conseiller scientifique sur cet essai clinique.<\/p>\n<p><span style=\"color: #69abb4;\"><strong>En r\u00e9sum\u00e9\u00a0:<\/strong><\/span><\/p>\n<ul>\n<li><strong>Cette \u00e9tude pilote a prouv\u00e9 la faisabilit\u00e9 et la tol\u00e9rance du dispositif RGn\u00a0de REGEnLIFE.<\/strong><\/li>\n<li><strong>Le dispositif RGn\u00a0est \u00e9galement s\u00fbr et permet un traitement non-invasif.<\/strong><\/li>\n<li><strong>Les patients se sont montr\u00e9s tr\u00e8s observants du traitement RGn.<\/strong><\/li>\n<li><strong>Cette \u00e9tude a mis en \u00e9vidence des tendances d&rsquo;efficacit\u00e9 sur le plan cognitif malgr\u00e9 le nombre r\u00e9duit de patients d\u00fb \u00e0 la fin pr\u00e9matur\u00e9e de l&rsquo;\u00e9tude \u00e0 cause de la COVID-19.<\/strong><\/li>\n<li><strong>Cette \u00e9tude fournit \u00e9galement des indications pr\u00e9cieuses pour la conception de la prochaine phase d&rsquo;essai clinique visant \u00e0 d\u00e9montrer, \u00e0 plus grande echelle, le b\u00e9n\u00e9fice cognitif du traitement RGn.<\/strong><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p align=\"justify\"><strong>R\u00e9f\u00e9rences\u00a0:<\/strong><\/p>\n<p align=\"justify\">Blivet et al., Safety and feasibility of the RGn, an innovative brain-gut photobiomodulation device, in mild-to-moderate Alzheimer\u2019s Disease patients: a randomized, double-blind and sham-controlled trial, Communication orale AD\/PD 2021.<\/p>\n<p><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full\/10.1016\/j.trci.2017.12.003\" target=\"_blank\" rel=\"noopener\">Guillaume Blivet, Johann Meunier, Francois J. Roman, Jacques Touchon &#8211; Neuroprotective effect of a new photobiomodulation technique against A\u03b225\u201335 peptide\u2013induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer&rsquo;s disease suggested, F\u00e9vrier 2018<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32617993\/\" target=\"_blank\" rel=\"noopener\">Yayi Sun et Al. &#8211; Intra-gastrointestinal amyloid-\u03b21-42 oligomers perturb enteric function and induce Alzheimer&rsquo;s disease pathology, Juillet 2020<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6326209\/\" target=\"_blank\" rel=\"noopener\">Karol Kowalski et Agata Mulak &#8211; Brain-Gut-Microbiota Axis in Alzheimer\u2019s Disease, Janvier 2019<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=\u00a0\u00bbstretch_row\u00a0\u00bb custom_css_code=\u00a0\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\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1753876521045{margin-bottom: 0px !important;padding-top: 85px !important;padding-bottom: 85px !important;background-color: #FFFFFF !important;}\u00a0\u00bb el_id=\u00a0\u00bbprecliniques\u00a0\u00bb][vc_column css=\u00a0\u00bb.vc_custom_1726578677849{padding-top: 0px !important;}\u00a0\u00bb][vc_row_inner content_placement=\u00a0\u00bbbottom\u00a0\u00bb][vc_column_inner][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<h4 style=\"text-align: left;\"><span style=\"color: #69abb4;\"><strong><span style=\"color: #aa689e;\">Etudes pr\u00e9cliniques r\u00e9alis\u00e9es par REGEnLIFE<\/span><\/strong><\/span><\/h4>\n<p>[\/vc_column_text][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<strong>Dans les \u00e9tudes pr\u00e9cliniques, le prototype RGn500 a montr\u00e9 son efficacit\u00e9 pour normaliser les d\u00e9ficits de m\u00e9moire et les changements biochimiques dans le mod\u00e8le murin A\u03b225-35, imitant les caract\u00e9ristiques pathologiques de la MA.<\/strong>[\/vc_column_text][vc_single_image image=\u00a0\u00bb4653&Prime; img_size=\u00a0\u00bblarge\u00a0\u00bb alignment=\u00a0\u00bbcenter\u00a0\u00bb css=\u00a0\u00bb\u00a0\u00bb][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<\/p>\n<p align=\"justify\">Dans les \u00e9tudes pr\u00e9cliniques, le prototype RGn500 a montr\u00e9 son efficacit\u00e9 pour normaliser les d\u00e9ficits de m\u00e9moire et les changements biochimiques dans le mod\u00e8le murin A\u03b225-35, imitant les caract\u00e9ristiques pathologiques de la MA.<\/p>\n<p align=\"justify\">Il est int\u00e9ressant de noter que cet effet neuroprotecteur, dans les configurations \u00e9tudi\u00e9es, n&rsquo;a \u00e9t\u00e9 observ\u00e9, uniquement lorsque la t\u00eate et l&rsquo;abdomen \u00e9taient expos\u00e9s (mais pas la t\u00eate seulement ou l&rsquo;abdomen seulement), ce qui sugg\u00e8re que plusieurs m\u00e9canismes sont impliqu\u00e9s, notamment l&rsquo;activation directe des chromophores cellulaires au niveau neuronal et les effets indirects r\u00e9sultant de l&rsquo;exposition abdominale. Cela sugg\u00e8re \u00e9galement qu\u2019une double exposition par PBM, sur la t\u00eate et l\u2019abdomen, augmenterait l\u2019efficacit\u00e9 th\u00e9rapeutique.<\/p>\n<p>[\/vc_column_text][vc_single_image image=\u00a0\u00bb4654&Prime; img_size=\u00a0\u00bblarge\u00a0\u00bb alignment=\u00a0\u00bbcenter\u00a0\u00bb css=\u00a0\u00bb\u00a0\u00bb][vc_single_image image=\u00a0\u00bb4655&Prime; img_size=\u00a0\u00bblarge\u00a0\u00bb alignment=\u00a0\u00bbcenter\u00a0\u00bb css=\u00a0\u00bb\u00a0\u00bb][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row equal_height=\u00a0\u00bbyes\u00a0\u00bb content_placement=\u00a0\u00bbtop\u00a0\u00bb custom_css_code=\u00a0\u00bbLmdlbS1pbWFnZS1jZW50ZXJlZC1ib3glMjAlN0IlMEElMjAlMjAlMjAlMjBtYXJnaW4tYm90dG9tJTNBJTIwMCUzQiUwQSU3RCUwQS5pbWctYm9yZGVyLXJhZGl1cyUyMGltZyU3QiUwQSUyMCUyMCUyMCUyMGJvcmRlci1yYWRpdXMlM0ElMjAzM3B4JTNCJTBBJTdEJTBBLmN1c3RvbS1pbmZvdGV4dCUyMCU3QiUwQSUyMCUyMCUyMCUyMHdpZHRoJTNBJTIwMjIwcHglM0IlMEElN0QlMEElNDBtZWRpYSUyOG1heC13aWR0aCUzQSUyMDk5MXB4JTI5JTdCJTBBJTIwJTIwJTIwJTIwLmN1c3RvbS1pbmZvdGV4dCUyMCU3QiUwQSUyMCUyMCUyMCUyMCUyMCUyMCUyMCUyMHdpZHRoJTNBJTIwMjAwcHglM0IlMEElMjAlMjAlMjAlMjAlN0QlMEElN0Q=\u00a0\u00bb thegem_revesrse_columns_mobile=\u00a0\u00bbtrue\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1751012676915{margin-bottom: 0px !important;padding-top: 85px !important;padding-bottom: 85px !important;}\u00a0\u00bb tablet_padding_top=\u00a0\u00bb160&Prime; el_class=\u00a0\u00bbCONTENEDORPIRATA\u00a0\u00bb mobile_padding_top=\u00a0\u00bb45&Prime;][vc_column width=\u00a0\u00bb1\/2&Prime; css=\u00a0\u00bb.vc_custom_1750698481768{padding-top: 0px !important;padding-right: 75px&#8230;<\/p>\n","protected":false},"author":1,"featured_media":3273,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-2995","page","type-page","status-publish","has-post-thumbnail"],"acf":[],"_links":{"self":[{"href":"https:\/\/regenlife.com\/fr\/wp-json\/wp\/v2\/pages\/2995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/regenlife.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/regenlife.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/regenlife.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/regenlife.com\/fr\/wp-json\/wp\/v2\/comments?post=2995"}],"version-history":[{"count":124,"href":"https:\/\/regenlife.com\/fr\/wp-json\/wp\/v2\/pages\/2995\/revisions"}],"predecessor-version":[{"id":6056,"href":"https:\/\/regenlife.com\/fr\/wp-json\/wp\/v2\/pages\/2995\/revisions\/6056"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/regenlife.com\/fr\/wp-json\/wp\/v2\/media\/3273"}],"wp:attachment":[{"href":"https:\/\/regenlife.com\/fr\/wp-json\/wp\/v2\/media?parent=2995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}