Devices for Preclinical Research
RGn530 and RGn535: innovative non-invasive medical devices using photobiomodulation (murine models).
REGEnLIFE markets the RGn530 and RGn535, miniaturized PBM neurostimulation medical devices for preclinical research, to treat neuroinflammation and neurological conditions in murine models.
The RGn530/RGn535 preclinical devices are adapted to the small size of mice and designed to immobilize them safely and securely. They take into account animal welfare principles, ensuring that mice experience only minimal discomfort during sessions. The devices, including a restraint shuttle, are composed of two modules: either cranial and abdominal (RGn530), or dorsoventral (RGn535). The abdominal or dorsoventral module is adjustable to adapt to the mouse’s morphology, while the cranial module is fixed, as the animal’s head does not vary with its body size.
Each module contains a mixed emission source of lasers (near-infrared) and LEDs (near-infrared and red). During treatment, mice are placed in a restraint capsule and then positioned in a dedicated slot on the device, allowing their head and abdomen to be placed under their respective modules.
RGn600 Treatment Features:
Customization
REGEnLIFE clinical devices: a flexible, customizable, and scalable modular design to adapt to research needs
REGEnLIFE medical devices for clinical research are modular to combine flexibility of use, therapeutic customization, and treatment precision. Indeed, the helmet and abdominal belt (RGn600) are composed of several independent, interconnectable modules that can be added or removed. These modular devices allow for individualized neurostimulation treatment by adjusting the number and position of modules according to individuals and targeted therapeutic goals.
Furthermore, the software configuration of the clinical devices allows for controlling and adapting PBM neurostimulation protocols to the specific needs of research work. Pre-established programs can thus be customized by the investigator. The modifiable parameters are:
- Laser type
- Types of optical components
- Wavelengths
- Irradiance
- Continuous or pulsed mode and the rhythm of PBM emissions
- Treatment duration
The modularity of REGEnLIFE devices and parameter optimization thus allow for adjusting protocols according to research needs and observed neurophysiological results.
